Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | MTOR | P42345 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 1/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eliprodil SCHEMBL7517402 | 1.00 | GMNN (1.00) | GMNNTP53CYP3A4ALOX15TSHR | |
| Eliprodil SCHEMBL154047 | 1.00 | GMNN (1.00) | GMNNTP53CYP3A4ALOX15TSHR | |
| Eliprodil SCHEMBL7521721 | 0.99 | GMNN (0.98) | GMNNTP53CYP3A4ALOX15TSHR | |
| Eliprodil SCHEMBL7212849 | 0.99 | GMNN (0.98) | GMNNTP53CYP3A4ALOX15TSHR | |
| Eliprodil SCHEMBL7525726 | 0.99 | GMNN (0.98) | GMNNTP53CYP3A4ALOX15TSHR | |
| SCHEMBL10732857 | 0.87 | MEN1 (0.82) | GMNNTP53CYP3A4ALOX15TSHR | |
| SCHEMBL21614247 | 0.85 | GMNN (0.74) | GMNNTP53CYP3A4ALOX15TSHR | |
| SCHEMBL467199 | 0.85 | GRIN2B (0.73) | GMNNTP53CYP3A4ALOX15TSHR | |
| SCHEMBL9258826 | 0.84 | GRIN1 (0.73) | GMNNTP53CYP3A4ALOX15TSHR | |
| Ifenprodil SCHEMBL1725512 | 0.83 | GRIN2B (0.69) | GMNNTP53CYP3A4ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718407-B1 | Intermediates for the synthesis of eliprodil enantiomers and process for their preparation | SANOFI SYNTHELABO (FR) | 2002-02-13 | — | — | EP | claimed |
| EP-0718407-A1 | Intermediates for the synthesis of eliprodil enantiomers and process for their preparation | SYNTHELABO (FR) | 1996-06-26 | — | — | EP | claimed |
| WO-2012075277-A2 | SYNTHETIC METHODS | NOVOMER, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| EP-1280528-B1 | R-ELIPRODIL FOR TREATING GLAUCOMA | ALCON INC (CH) | 2005-03-23 | — | — | EP | disclosed |
| US-20030212107-A1 | R-reliprodil for treating glaucoma | ALCON UNIVERSAL LTD. (CH) | 2003-11-13 | — | — | US | disclosed |
| EP-1280528-A2 | R-ELIPRODIL FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2003-02-05 | — | — | EP | disclosed |
| EP-0718407-B1 | Intermediates for the synthesis of eliprodil enantiomers and process for their preparation | SANOFI SYNTHELABO (FR) | 2002-02-13 | — | — | EP | disclosed |
| WO-2001085152-A2 | R-ELIPRODIL FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-11-15 | — | — | WO | disclosed |
| WO-2001085169-A2 | R-ELIPRODIL FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-11-15 | — | — | WO | disclosed |
| US-5677168-A | Enantiomeric separation of (RS)1-(4-chlorophenyl)-2-chloroethanol by lipase catalyzed hydrolysis of its acetate | SYNTHELABO (FR) | 1997-10-14 | — | — | US | disclosed |
| US-5620990-A | NERVOUS SYSTEM DISORDERS | SYNTHELABO (FR) | 1997-04-15 | — | — | US | disclosed |
| EP-0718407-A1 | Intermediates for the synthesis of eliprodil enantiomers and process for their preparation | SYNTHELABO (FR) | 1996-06-26 | — | — | EP | disclosed |
| CN-1120038-A | Substituted ester of piperidine-1-alcohol, preparation and pharmaceutical use of same | SYNTHELABO (FR) | 1996-04-10 | — | — | CN | disclosed |
| EP-0692472-A1 | Alpha-(4-chlorophenyl)- 4-(4-fluorophenylmethyl)-piperidine-1 -ethanol esters, their preparation and therapeutical use | SYNTHELABO (FR) | 1996-01-17 | — | — | EP | disclosed |