Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ECE1 | P42892 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.43 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.43 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.43 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244495 | 0.89 | KDM4E (0.61) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL29357675 | 0.83 | KDM4E (0.76) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL70765 | 0.83 | KDM4E (0.76) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL29355234 | 0.81 | KDM4E (0.73) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL143651 | 0.81 | KDM4E (0.73) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL9220648 | 0.81 | CTSS (0.55) | KDM4EALOX15TDP1CES1CTSS | |
| SCHEMBL29988787 | 0.81 | CTSS (0.55) | KDM4EALOX15TDP1CES1CTSS | |
| SCHEMBL17258380 | 0.81 | CYP1A2 (0.43) | CES1AHR | |
| SCHEMBL5611442 | 0.80 | KDM4E (0.55) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL23069157 | 0.79 | KDM4E (0.70) | KDM4EALOX15TSHRACMSDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469656-B2 | HDAC inhibitors as anti-cancer agents | THE UNIVERSITY OF TOLEDO (US) | 2016-10-18 | — | — | US | disclosed |
| US-20150329560-A1 | HDAC Inhibitors as Anti-Cancer Agents | THE UNIVERSITY OF TOLEDO (US) | 2015-11-19 | — | — | US | disclosed |
| WO-2015175770-A1 | HDAC INHIBITORS AS ANTI-CANCER AGENTS | THE UNIVERSITY OF TOLEDO (US) | 2015-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329560-A1 | HDAC Inhibitors as Anti-Cancer Agents | HDAC1, HDAC4, HDAC5 | KDM4E 188/4885ALOX15 3734/4885TSHR 4383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.