⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10596008 | 0.73 | ALDH1A1 (0.32) | — | |
| SCHEMBL25815434 | 0.68 | CHRM2 (0.39) | — | |
| SCHEMBL3068640 | 0.68 | — | — | |
| SCHEMBL176040 | 0.68 | CHRM2 (0.39) | — | |
| SCHEMBL31247892 | 0.68 | CHRM2 (0.39) | — | |
| SCHEMBL24752922 | 0.66 | CHRM2 (0.43) | — | |
| SCHEMBL18215078 | 0.65 | — | — | |
| SCHEMBL6302095 | 0.64 | — | — | |
| SCHEMBL29551263 | 0.64 | CHRM2 (0.30) | — | |
| SCHEMBL16878503 | 0.64 | CHRM2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780841-B2 | 3,6-methano-1H-pyrrolo[3,2-b]pyridine and 3,6-methano-1H-pyrrolo[3,2-c]pyridine compounds and medicaments using same | IRIMAJIRI THERAPEUTICS INC. (JP) | 2023-10-10 | — | — | US | disclosed |
| US-20220194942-A1 | 3,6-METHANO-1H-PYRROLO[3,2-b]PYRIDINE AND 3,6-METHANO-1H-PYRROLO[3,2-c]PYRIDINE COMPOUNDS AND MEDICAMENTS USING SAME | IRIMAJIRI THERAPEUTICS INC. (JP) | 2022-06-23 | — | — | US | disclosed |
| US-20210214356-A1 | COMPOUNDS AND MEDICAMENTS USING SAME | IRIMAJIRI THERAPEUTICS INC. (JP) | 2021-07-15 | — | — | US | disclosed |
| US-10022376-B2 | Pyrazolopyridines and pyrazolopyrimidines | PFIZER INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170071946-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. (US) | 2017-03-16 | — | — | US | disclosed |
| US-9518052-B2 | Pyrazolopyridines and pyrazolopyrimidines | PFIZER INC. (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150329542-A1 | PYRAZOLOPYRIDINES AND PYRAZOLOPYRIMIDINES | PFIZER INC. | 2015-11-19 | — | — | US | disclosed |