Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MC1R | Q01726 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147328 | 1.00 | DPP4 (0.63) | DPP4DRD2DRD3CCR5ACHE | |
| SCHEMBL147329 | 1.00 | DPP4 (0.63) | DPP4DRD2DRD3CCR5ACHE | |
| SCHEMBL147330 | 1.00 | DPP4 (0.63) | DPP4DRD2DRD3CCR5ACHE | |
| SCHEMBL14730218 | 0.90 | DPP4 (0.63) | DPP4DRD2DRD3CCR5ACHE | |
| SCHEMBL6125565 | 0.90 | DPP4 (0.63) | DPP4DRD2DRD3CCR5ACHE | |
| SCHEMBL470566 | 0.88 | DPP4 (0.77) | DPP4DRD2DRD3CCR5HTR2A | |
| SCHEMBL1203772 | 0.87 | DPP4 (0.60) | DPP4DRD2DRD3CCR5ACHE | |
| SCHEMBL1203774 | 0.87 | DPP4 (0.60) | DPP4DRD2DRD3CCR5ACHE | |
| SCHEMBL149731 | 0.86 | DPP4 (0.64) | DPP4DRD2DRD3CCR5 | |
| SCHEMBL149730 | 0.86 | DPP4 (0.64) | DPP4DRD2DRD3CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406251-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103334-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |