Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | KDM1A | O60341 | 2/20 | 0.51 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.51 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | BACE1 | P56817 | 4/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6125565 | 1.00 | DPP4 (0.63) | DPP4DRD2DRD3KDM1AKDM1B | |
| SCHEMBL13186450 | 0.90 | ACHE (0.52) | DPP4DRD2DRD3KDM1AKDM1B | |
| SCHEMBL147330 | 0.90 | DPP4 (0.63) | DPP4DRD2DRD3KDM1ACCR5 | |
| SCHEMBL1725958 | 0.90 | DPP4 (0.63) | DPP4DRD2DRD3KDM1ACCR5 | |
| SCHEMBL147328 | 0.90 | DPP4 (0.63) | DPP4DRD2DRD3KDM1ACCR5 | |
| SCHEMBL147329 | 0.90 | DPP4 (0.63) | DPP4DRD2DRD3KDM1ACCR5 | |
| SCHEMBL470654 | 0.87 | DPP4 (0.60) | DPP4DRD2DRD3CCR5ACHE | |
| SCHEMBL149731 | 0.86 | DPP4 (0.64) | DPP4DRD2DRD3CCR5KCNH2 | |
| SCHEMBL149730 | 0.86 | DPP4 (0.64) | DPP4DRD2DRD3CCR5KCNH2 | |
| SCHEMBL149732 | 0.86 | DPP4 (0.64) | DPP4DRD2DRD3CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |