Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 11/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 2/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 1/20 | 0.50 |
| ▸ | SLC11A2 | P49281 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13007589 | 0.98 | IDO1 (0.57) | IDO1HTTLMNASMN1; SMN2TAAR1 | |
| Bromide SCHEMBL2810146 | 0.82 | IDO1 (0.71) | IDO1HTTLMNASMN1; SMN2TAAR1 | |
| SCHEMBL2812696 | 0.80 | IDO1 (0.74) | IDO1HTTLMNASMN1; SMN2TAAR1 | |
| Hydrochloric Acid SCHEMBL22263112 | 0.78 | IDO1 (0.75) | IDO1HTTLMNASMN1; SMN2TAAR1 | |
| SCHEMBL3773680 | 0.78 | IDO1 (0.61) | IDO1HTTLMNASMN1; SMN2TAAR1 | |
| Bromide SCHEMBL2409774 | 0.77 | IDO1 (0.50) | IDO1ALDH1A1 | |
| Bromide SCHEMBL4919108 | 0.77 | IDO1 (0.61) | IDO1HTTLMNASMN1; SMN2TAAR1 | |
| Bromide SCHEMBL5552297 | 0.76 | HTT (0.53) | IDO1HTTLMNASMN1; SMN2TAAR1 | |
| SCHEMBL15928217 | 0.76 | IDO1 (0.51) | IDO1HTTLMNASMN1; SMN2TAAR1 | |
| SCHEMBL13007585 | 0.75 | IDO1 (0.62) | IDO1HTTLMNASMN1; SMN2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015173035-A1 | HERBICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2015-11-19 | — | — | WO | disclosed |