Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 9/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CASP1 | P29466 | 2/20 | 0.61 |
| ▸ | HBB | P68871 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALPG | P10696 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726254 | 1.00 | APP (1.00) | APPRELAMAPTMEN1KMT2A | |
| SCHEMBL12319187 | 1.00 | APP (1.00) | APPRELAMAPTMEN1KMT2A | |
| SCHEMBL1714449 | 0.88 | RELA (0.81) | APPRELAMAPTMEN1KMT2A | |
| SCHEMBL1714446 | 0.88 | RELA (0.81) | APPRELAMAPTMEN1KMT2A | |
| SCHEMBL7915381 | 0.88 | RELA (0.81) | APPRELAMAPTMEN1KMT2A | |
| SCHEMBL13467434 | 0.88 | RELA (0.81) | APPRELAMAPTMEN1KMT2A | |
| SCHEMBL3025040 | 0.88 | RELA (0.81) | APPRELAMAPTMEN1KMT2A | |
| SCHEMBL29389358 | 0.85 | RELA (0.77) | APPRELAMAPTMEN1KMT2A | |
| SCHEMBL671950 | 0.85 | APP (0.73) | APPMAPTMEN1KMT2AHBB | |
| SCHEMBL23908232 | 0.81 | RELA (0.71) | APPRELAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2042501-B1 | COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDIPHYSICS CO LTD (JP) | 2017-04-12 | — | — | EP | disclosed |
| EP-2716641-B1 | RADIOACTIVE IODINE LABELED COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDIPHYSICS CO LTD (JP) | 2017-04-05 | — | — | EP | disclosed |
| EP-2725027-B1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | NIHON MEDIPHYSICS CO LTD (JP) | 2017-03-01 | — | — | EP | disclosed |
| US-9211350-B2 | Compound with amyloid affinity | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2015-12-15 | — | — | US | disclosed |
| US-9149546-B2 | Compound having affinity for amyloid | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20140335019-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND ANALYSIS OF NEUROLOGICAL DISORDERS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2014-11-13 | — | — | US | disclosed |
| US-20140228569-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2014-08-14 | — | — | US | disclosed |
| US-20140121377-A1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2014-05-01 | — | — | US | disclosed |
| EP-2725027-A1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | Nihon Medi-Physics Co., Ltd. (JP) | 2014-04-30 | — | — | EP | disclosed |
| EP-1432453-B1 | STILBENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES | UNIV PENNSYLVANIA (US) | 2013-08-14 | — | — | EP | disclosed |
| US-7297820-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-11-20 | — | — | US | disclosed |
| US-7297820-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-11-20 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2007-11-01 | — | — | US | disclosed |
| US-7250525-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250525-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250525-B2 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-07-31 | — | — | US | disclosed |
| US-20060002853-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-01-05 | — | — | US | disclosed |
| US-20030149250-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2003-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060002853-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | APP, APBA1, PSEN1 | APP 1/4885RELA 2968/4885MAPT 6/4885 |
| US-20140228569-A1 | NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID | APP, APBA1, BACE1 | APP 1/4885RELA 1907/4885MAPT 14/4885 |
| US-20070254889-A1 | Compounds and methods useful for rescuing cells from beta-amyloid toxicity and treatment of Alzheimer's disease | APP, BACE1, IAPP | APP 1/4885RELA 2689/4885MAPT 13/4885 |
| US-20140335019-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT AND ANALYSIS OF NEUROLOGICAL DISORDERS | PSEN1, PSEN2, APP | APP 3/4885RELA 4598/4885MAPT 5/4885 |
| US-20140121377-A1 | NOVEL COMPOUND WITH AMYLOID AFFINITY | APP, APBA1, BACE1 | APP 1/4885RELA 1675/4885MAPT 8/4885 |
| US-20030149250-A1 | Stilbene derivatives and their use for binding and imaging amyloid plaques | APP, APBA1, PSEN1 | APP 1/4885RELA 2968/4885MAPT 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.