Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.71 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.65 |
| ▸ | MC5R | P33032 | 1/20 | 0.64 |
| ▸ | MC3R | P41968 | 1/20 | 0.64 |
| ▸ | MC1R | Q01726 | 1/20 | 0.64 |
| ▸ | G6PD | P11413 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | HTR1D | P28221 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724528 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL1725569 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL1724670 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL1726381 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL1725374 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL22411429 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL14907395 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL7022564 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL1727120 | 1.00 | HTR2A (0.71) | HTR2AMTNR1AMC5RMC3RMC1R | |
| SCHEMBL1325639 | 0.99 | HTR2A (0.73) | HTR2AMTNR1AMC5RMC3RMC1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614246-B2 | Indole derivatives for treating neurodegenerative diseases | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2013-12-24 | — | — | US | disclosed |
| CN-102369185-A | Indole derivatives for treating neurodegenerative diseases | CENTRE NAT RECH SCIENT | 2012-03-07 | — | — | CN | disclosed |
| EP-2403830-A2 | INDOLE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | Centre National de la Recherche Scientifique (CNRS) (FR) | 2012-01-11 | — | — | EP | disclosed |
| US-20110319387-A1 | INDOLE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2011-12-29 | — | — | US | disclosed |
| WO-2010100133-A2 | INDOLE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319387-A1 | INDOLE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | SNCA, TPH1, HCRTR1 | HTR2A 91/4885MTNR1A 20/4885MC5R 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.