Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | BACE1 | P56817 | 4/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726510 | 1.00 | DPP4 (0.49) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL149025 | 1.00 | DPP4 (0.49) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL119907 | 1.00 | DPP4 (0.49) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL149024 | 1.00 | DPP4 (0.49) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL14722767 | 0.91 | DPP4 (0.41) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL459874 | 0.91 | DPP4 (0.41) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL14722768 | 0.91 | DPP4 (0.41) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL5924076 | 0.91 | DPP4 (0.46) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL149641 | 0.89 | DRD2 (0.49) | DPP4DRD2DRD3ACHEBACE1 | |
| SCHEMBL121059 | 0.89 | DRD2 (0.49) | DPP4DRD2DRD3ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406251-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103334-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |