Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 3/20 | 0.61 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.54 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | PLAA | Q9Y263 | 2/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12979260 | 0.83 | PLOD2 (0.54) | PLOD2PLOD3PLOD1CA12CA1 | |
| SCHEMBL4294261 | 0.80 | PLOD2 (0.50) | PLOD2PLOD3PLOD1CA12CA1 | |
| SCHEMBL1095373 | 0.79 | PLOD2 (0.72) | PLOD2PLOD3PLOD1L3MBTL1KDM4E | |
| SCHEMBL1925141 | 0.79 | PLOD2 (0.66) | PLOD2PLOD3PLOD1 | |
| SCHEMBL1925145 | 0.77 | PLOD2 (0.59) | PLOD2PLOD3PLOD1HDAC6POLB | |
| SCHEMBL1349410 | 0.77 | PLOD2 (0.59) | PLOD2PLOD3PLOD1HDAC6KDM4E | |
| SCHEMBL4587759 | 0.77 | PLOD2 (0.59) | PLOD2PLOD3PLOD1L3MBTL1GAA | |
| SCHEMBL12332698 | 0.77 | CA12 (0.59) | HDAC6CA12CA1CA2CA7 | |
| SCHEMBL592024 | 0.76 | PLOD2 (0.57) | PLOD2PLOD3PLOD1CA12CA1 | |
| SCHEMBL29524110 | 0.76 | PLOD2 (0.57) | PLOD2PLOD3PLOD1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015173164-A1 | NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-19 | — | — | WO | disclosed |