Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.36 |
| ▸ | ADH1B | P00325 | 2/20 | 0.36 |
| ▸ | ADH1C | P00326 | 2/20 | 0.36 |
| ▸ | ADH1A | P07327 | 2/20 | 0.36 |
| ▸ | ADH7 | P40394 | 2/20 | 0.36 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.34 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22419042 | 0.96 | TSHR (0.42) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL20036791 | 0.93 | TSHR (0.52) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL21498936 | 0.93 | TSHR (0.46) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL23761565 | 0.91 | TSHR (0.50) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL9208301 | 0.91 | TSHR (0.50) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL21162272 | 0.91 | TSHR (0.46) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL17919006 | 0.91 | TSHR (0.43) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL23763807 | 0.91 | TSHR (0.46) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL12285467 | 0.91 | TSHR (0.43) | TSHRALDH1A1CYP3A4ANPEPERAP2 | |
| SCHEMBL9407527 | 0.87 | TSHR (0.52) | TSHRALDH1A1CYP3A4ANPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255738-B1 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2012-03-07 | — | — | EP | disclosed |