Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 2/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.45 |
| ▸ | CLK2 | P49760 | 2/20 | 0.45 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19283001 | 0.96 | HDAC1 (0.51) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| SCHEMBL17267635 | 0.92 | DYRK3 (0.47) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| SCHEMBL28912855 | 0.85 | DYRK3 (0.42) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| SCHEMBL17596825 | 0.83 | HDAC1 (0.46) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| SCHEMBL17699271 | 0.82 | SRC (0.44) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| SCHEMBL29998891 | 0.81 | ADK (0.47) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| SCHEMBL27088098 | 0.81 | ADK (0.47) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL29669723 | 0.81 | JAK2 (0.43) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| SCHEMBL20553297 | 0.81 | BTK (0.42) | HDAC1DYRK3CDK1ROS1RPS6KB1 | |
| Trifluoroacetic Acid SCHEMBL21528118 | 0.81 | JAK2 (0.43) | HDAC1DYRK3CDK1ROS1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2947086-B1 | NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2018-01-03 | — | — | EP | disclosed |
| EP-2947086-A1 | NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2015-11-25 | — | — | EP | disclosed |