Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26493869 | 0.97 | MAPT (0.45) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7299330 | 0.94 | CHRM2 (0.48) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL26493908 | 0.94 | CHRM2 (0.48) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL28007188 | 0.94 | MAPT (0.43) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA | |
| Bromide SCHEMBL28007182 | 0.92 | MAPT (0.45) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL465323 | 0.91 | CHRM2 (0.48) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL3428918 | 0.88 | — | — | |
| SCHEMBL9762163 | 0.88 | CHRM2 (0.52) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8376760 | 0.88 | CHRM2 (0.52) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL465397 | 0.88 | CHRM2 (0.52) | MAPTCHRM2SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150335547-A1 | ORAL CARE COMPOSITION CONTAINING IONIC LIQUIDS | COLGATE-PALMOLIVE COMPANY (US) | 2015-11-26 | — | — | US | disclosed |
| CN-104853737-A | ORAL CARE COMPOSITION CONTAINING IONIC LIQUIDS | COLGATE PALMOLIVE CO | 2015-08-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150335547-A1 | ORAL CARE COMPOSITION CONTAINING IONIC LIQUIDS | MCOLN3, TAS2R39, TAS2R40 | CHRM2 1877/4885SIGMAR1 905/4885MAPT 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.