TAS2R40

Taste receptor type 2 member 40 · P59535 · TAS2R40 on Sugi Atlas →

978 patent compounds predicted against TAS2R40, 850 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Isoproterenol (SCHEMBL4165)	1.00	1/20
Isoproterenol (SCHEMBL4166)	1.00	1/20
Levisoprenaline (SCHEMBL250806)	1.00	1/20
Isoproterenol (SCHEMBL3253794)	1.00	1/20
Isoproterenol (SCHEMBL7627)	0.97	1/20
Isoproterenol (SCHEMBL1333049)	0.97	1/20
Isoproterenol (SCHEMBL3672791)	0.97	1/20
Levisoprenaline (SCHEMBL4745572)	0.97	1/20
Isoproterenol (SCHEMBL5682030)	0.97	1/20
Isoproterenol (SCHEMBL6151626)	0.97	1/20
Isoproterenol (SCHEMBL9614622)	0.97	1/20
Isoproterenol (SCHEMBL3669257)	0.93	1/20
Isoproterenol (SCHEMBL2232971)	0.88	1/20
Isoproterenol (SCHEMBL41841)	0.85	1/20
Metaproterenol (SCHEMBL3841247)	0.85	1/20
Isoproterenol (SCHEMBL7268328)	0.85	1/20
Isoproterenol (SCHEMBL9237796)	0.85	1/20
Isoproterenol (SCHEMBL582812)	0.82	1/20
Isoproterenol (SCHEMBL5682034)	0.82	1/20
Isoproterenol (SCHEMBL559248)	0.80	1/20

Clinical trials — most relevant to TAS2R40 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Trial of Efficacy and Safety of Raphamin in the Treatment of Coronavirus Disease 2019 in Outpatients	PHASE3	COMPLETED
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults	nan	COMPLETED
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries	nan	COMPLETED
Allele-specific Expression of a Bitter Taste Receptor	nan	COMPLETED
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste	nan	COMPLETED
NUTRACORE, Glycaemic Index and Appetite	nan	COMPLETED
The Effect of Lactisole on the Responses to Glucose Solution	nan	UNKNOWN
Flavour Programming: Fruit and Vegetable Palatability	nan	COMPLETED
A Study of the Function of Hormones Present In Taste Buds	nan	COMPLETED
Sensory Study: Taste and Tongue Biology	nan	COMPLETED
Bitter Taste Receptors in Oropharynx Cancer	nan	UNKNOWN
Astringency and Oral Health	nan	COMPLETED
Study of Taste Deficits	nan	COMPLETED
Taste Perception and Chronic Disease Risk	nan	COMPLETED
Ibuprofen Inhibits Human Sweet Taste	nan	COMPLETED
Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults	nan	COMPLETED
Sucralose and Lactisole Additions to OGTT in Humans	nan	COMPLETED
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
The Obese Taste Bud Study	nan	UNKNOWN
Genetic Variability in Taste Perception	nan	COMPLETED
CD36 and Human Fat Taste Perception	nan	COMPLETED
The Effect of Artificial Sweeteners on Blood Glucose Response	nan	WITHDRAWN
Impacts of Sugar-Sweetened Beverage on Body Weight	nan	COMPLETED
Sensitive Periods in Early Flavor Learning	nan	COMPLETED
Taste Physiology in Healthy, Normal-weight Volunteers	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TAS2R40 binder may also engage these)

Protein	Name	Similarity
Q646B1	—	1.000	Q646B1 →
Q645Y9	—	1.000	Q645Y9 →
Q646F2	—	1.000	Q646F2 →
Q645U5	—	1.000	Q645U5 →
Q646D4	—	0.998	Q646D4 →
Q67ET2	—	0.995	Q67ET2 →
Q646A5	—	0.995	Q646A5 →
TAS2R39	Taste receptor type 2 member 39	0.995	landscape →
Q67ES3	—	0.994	Q67ES3 →
TAS2R60	Taste receptor type 2 member 60	0.994	landscape →
Q645Y7	—	0.994	Q645Y7 →
Q67ER9	—	0.993	Q67ER9 →
Q646C8	—	0.993	Q646C8 →
Q697L5	—	0.993	Q697L5 →
TAS2R38	Taste receptor type 2 member 38	0.993	landscape →
Q646F0	—	0.993	Q646F0 →
Q646D0	—	0.992	Q646D0 →
Q7TQA6	—	0.992	Q7TQA6 →
TAS2R1	Taste receptor type 2 member 1	0.992	landscape →
Q645Y8	—	0.992	Q645Y8 →
Q645U1	—	0.992	Q645U1 →
Q7TQB9	—	0.992	Q7TQB9 →
Q646B2	—	0.991	Q646B2 →
Q7TQB8	—	0.991	Q7TQB8 →
Q646A4	—	0.991	Q646A4 →
Q7TQA5	—	0.991	Q7TQA5 →
Q697L6	—	0.991	Q697L6 →
Q646B3	—	0.991	Q646B3 →
Q9JKU0	—	0.991	Q9JKU0 →
Q697L2	—	0.990	Q697L2 →