Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17273747 | 0.88 | SMN1; SMN2 (0.54) | TP53MAPTLMNAPOLBATM | |
| SCHEMBL17273749 | 0.86 | POLB (0.60) | TP53MAPTLMNAPOLBATM | |
| SCHEMBL17273750 | 0.84 | MAPT (0.61) | TP53MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL17261519 | 0.79 | HSD17B10 (0.60) | TP53MAPTLMNAPOLBATM | |
| SCHEMBL17273814 | 0.79 | HSD17B10 (0.60) | TP53MAPTLMNAPOLBATM | |
| SCHEMBL17273813 | 0.78 | HSD17B10 (0.61) | TP53MAPTLMNAPOLBATM | |
| SCHEMBL3536387 | 0.76 | HTR2C (0.57) | TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL3535676 | 0.76 | HTR2C (0.57) | TP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL4900754 | 0.74 | LMNA (0.45) | TP53MAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL4894623 | 0.72 | LMNA (0.46) | TP53MAPTLMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015172196-A1 | HETEROCYCLIC COMPOUNDS AND USE OF SAME | MONASH UNIVERSITY (AU) | 2015-11-19 | — | — | WO | disclosed |