Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 9/20 | 0.65 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.47 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.47 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.47 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.47 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4F8 | P98187 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18764213 | 0.84 | NAAA (0.59) | NAAA | |
| SCHEMBL17274393 | 0.82 | NAAA (0.63) | NAAA | |
| SCHEMBL17274405 | 0.79 | NAAA (1.00) | NAAA | |
| SCHEMBL17274391 | 0.77 | NAAA (0.63) | NAAASYK | |
| SCHEMBL6275646 | 0.75 | CYP1A1 (0.59) | NAAACYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL1687446 | 0.75 | CYP1A1 (0.59) | NAAACYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL22412744 | 0.75 | SLC6A4 (0.58) | NAAASLC6A4HTR2CHTR2B | |
| SCHEMBL17599105 | 0.74 | CYP1A1 (0.71) | NAAACYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL5893516 | 0.74 | CYP1A1 (0.57) | NAAACYP1A1CYP1A2CYP2E1CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL20451601 | 0.73 | NAAA (0.48) | NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145505-A1 | N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF | Northeastern University (US) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015179190-A1 | N-ACYLETHANOLAMINE HYDROLYZING ACID AMIDASE (NAAA) INHIBITORS AND THEIR USE THEREOF | NORTHEASTERN UNIVERSITY (US) | 2015-11-26 | — | — | WO | disclosed |