SCHEMBL1727477

SCHEMBL1727477

O=C(O)NCCC1CCN(c2cccc(C(F)(F)F)c2)CC1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM4 P08173 3/20 0.66
NOTUM Q6P988 1/20 0.58
POLB P06746 2/20 0.53
CHRM2 P08172 4/20 0.53
LMNA P02545 4/20 0.52
HTT P42858 1/20 0.52
DRD2 P14416 1/20 0.52
DRD3 P35462 1/20 0.52
HRH3 Q9Y5N1 1/20 0.51
CHRM1 P11229 1/20 0.51
KDM4E B2RXH2 1/20 0.49
ALDH1A1 P00352 1/20 0.49
MAPT P10636 1/20 0.49
MEN1 O00255 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL240152 0.84 CHRM4 (0.56) CHRM4NOTUMPOLBCHRM2LMNA
SCHEMBL3265586 0.82 CHRM4 (0.54) CHRM4NOTUMPOLBCHRM2LMNA
SCHEMBL548108 0.82 NOTUM (0.59) CHRM4NOTUMPOLBLMNAHTT
SCHEMBL3938442 0.81 CHRM4 (0.66) CHRM4CHRM2CHRM1
SCHEMBL239283 0.81 HRH3 (0.58) CHRM4NOTUMPOLBLMNAHTT
SCHEMBL1710848 0.80 CHRM2 (0.49) CHRM4CHRM2CHRM1KMT2A
SCHEMBL29432091 0.80 CHRM4 (1.00) CHRM4CHRM2CHRM1
SCHEMBL1410310 0.80 NOTUM (0.66) CHRM4NOTUMPOLBLMNAHTT
SCHEMBL1728821 0.79 CHRM4 (0.68) CHRM4CHRM2HRH3CHRM1KDM4E
SCHEMBL1727883 0.79 NOTUM (0.55) CHRM4NOTUMPOLBLMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1633735-B1 DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS SANOFI SA (FR) 2011-11-30 EP claimed
EP-1633735-B1 DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS SANOFI SA (FR) 2011-11-30 EP disclosed
EP-1633735-A1 DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS Sanofi-Aventis (FR) 2006-03-15 EP disclosed
WO-2004099176-A1 DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS SANOFI-AVENTIS (FR) 2004-11-18 WO disclosed