Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30036421 | 0.86 | TDP1 (0.59) | POLBAPEX1RECQLTDP1MAPT | |
| SCHEMBL1092598 | 0.76 | TDP1 (0.77) | POLBAPEX1RECQLTDP1MAPT | |
| SCHEMBL28321959 | 0.76 | ESR1 (0.38) | NPC1RAB9ACYP4F2CYP4A11ESR1 | |
| SCHEMBL10368981 | 0.74 | POLB (0.45) | POLBAPEX1RECQLITGB3ITGA2B | |
| Tremetone SCHEMBL4743840 | 0.73 | POLB (0.75) | POLBAPEX1RECQLTDP1MAPT | |
| Tremetone SCHEMBL4743839 | 0.73 | POLB (0.75) | POLBAPEX1RECQLTDP1MAPT | |
| SCHEMBL7979003 | 0.72 | CYP4F2 (0.46) | POLBAPEX1RECQLTDP1MAPT | |
| SCHEMBL102518 | 0.72 | PRKCI (0.62) | MAPTNPC1RAB9AKDM4E | |
| SCHEMBL29793780 | 0.72 | PRKCI (0.62) | MAPTNPC1RAB9AKDM4E | |
| SCHEMBL32779 | 0.71 | NPC1 (0.49) | POLBAPEX1RECQLMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403840-A1 | DERIVATIVES OF BENZOTHIAZINES, PREPARATION THEREOF AND APPLICATION THEREOF AS DRUGS | Pierre Fabre Médicament (FR) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100139-A1 | DERIVATIVES OF BENZOTHIAZINES, PREPARATION THEREOF AND APPLICATION THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 2010-09-10 | — | — | WO | disclosed |