Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 12/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 10/20 | 0.44 |
| ▸ | PRKCA | P17252 | 3/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 7/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17277167 | 1.00 | PRKCQ (0.44) | PRKCQPRKCDPRKCAPIM1SMO | |
| SCHEMBL17277170 | 0.90 | PRKCQ (0.52) | PRKCQPRKCDPRKCAPIM1 | |
| SCHEMBL17277169 | 0.90 | PRKCQ (0.52) | PRKCQPRKCDPRKCAPIM1 | |
| SCHEMBL9882031 | 0.87 | PRKCQ (0.47) | PRKCQPRKCDPRKCAPIM1 | |
| SCHEMBL15273584 | 0.87 | PRKCQ (0.47) | PRKCQPRKCDPRKCAPIM1 | |
| SCHEMBL9882083 | 0.87 | PRKCQ (0.47) | PRKCQPRKCDPRKCAPIM1 | |
| SCHEMBL15273585 | 0.87 | PRKCQ (0.47) | PRKCQPRKCDPRKCAPIM1 | |
| SCHEMBL9882089 | 0.87 | PRKCQ (0.47) | PRKCQPRKCDPRKCAPIM1 | |
| SCHEMBL9882029 | 0.87 | PRKCQ (0.47) | PRKCQPRKCDPRKCAPIM1 | |
| SCHEMBL15273630 | 0.86 | PRKCQ (0.49) | PRKCQPRKCDPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193722-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193722-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-24 | — | — | US | disclosed |