Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14764 | 0.87 | SLC6A2 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL12062136 | 0.87 | SLC6A2 (0.46) | SLC6A2SLC6A4KCNH2SLC6A3HTR6 | |
| SCHEMBL17277329 | 0.86 | SLC6A2 (0.49) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL17277309 | 0.82 | HTR2A (0.44) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL17277488 | 0.81 | HTR2A (0.49) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL17277400 | 0.81 | HTR2A (0.48) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL17277566 | 0.80 | SLC6A2 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL17277570 | 0.78 | SLC6A2 (0.46) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL17277315 | 0.78 | SLC6A2 (0.46) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C | |
| SCHEMBL17277564 | 0.77 | SLC6A2 (0.51) | SLC6A2SLC6A4KCNH2SLC6A3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |