Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.84 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.77 |
| ▸ | FAAH | O00519 | 2/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.65 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | UBE2N | P61088 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728074 | 1.00 | MTNR1A (0.84) | MTNR1ATRPV1FAAHPTGS2MEN1 | |
| SCHEMBL1728072 | 1.00 | MTNR1A (0.84) | MTNR1ATRPV1FAAHPTGS2MEN1 | |
| SCHEMBL25080192 | 1.00 | MTNR1A (0.84) | MTNR1ATRPV1FAAHPTGS2MEN1 | |
| SCHEMBL29926137 | 0.98 | MTNR1A (0.87) | MTNR1ATRPV1FAAHPTGS2MEN1 | |
| SCHEMBL1724741 | 0.92 | MTNR1A (1.00) | MTNR1ATRPV1MEN1KMT2AMAPT | |
| SCHEMBL1725354 | 0.92 | MTNR1A (1.00) | MTNR1ATRPV1MEN1KMT2AMAPT | |
| SCHEMBL1066221 | 0.92 | MTNR1A (1.00) | MTNR1ATRPV1MEN1KMT2AMAPT | |
| SCHEMBL3806536 | 0.92 | MTNR1A (1.00) | MTNR1ATRPV1MEN1KMT2AMAPT | |
| SCHEMBL1727281 | 0.92 | MTNR1A (1.00) | MTNR1ATRPV1MEN1KMT2AMAPT | |
| SCHEMBL22411433 | 0.92 | MTNR1A (1.00) | MTNR1ATRPV1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403830-A2 | INDOLE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | Centre National de la Recherche Scientifique (CNRS) (FR) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100133-A2 | INDOLE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-09-10 | — | — | WO | disclosed |