Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.65 |
| ▸ | AHR | P35869 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 13/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259230 | 0.81 | BRAF (0.58) | BRAFTNNI3KAHREGFRERBB2 | |
| SCHEMBL12067100 | 0.79 | TNNI3K (1.00) | BRAFTNNI3KEGFR | |
| SCHEMBL5564873 | 0.76 | KDR (0.55) | BRAFTNNI3KEGFRKDRRET | |
| SCHEMBL17274798 | 0.76 | AHR (0.53) | BRAFTNNI3KAHREGFRERBB2 | |
| SCHEMBL4393321 | 0.75 | AHR (0.97) | AHREGFRERBB2AURKBKDR | |
| SCHEMBL16962073 | 0.74 | MKNK1 (0.73) | BRAFTNNI3KEGFRERBB2RET | |
| SCHEMBL5559336 | 0.73 | KDR (0.63) | BRAFTNNI3KEGFRKDRRET | |
| SCHEMBL15618410 | 0.73 | BRAF (0.48) | BRAFTNNI3KEGFRAURKAAURKB | |
| SCHEMBL15618296 | 0.73 | MKNK1 (0.58) | BRAFTNNI3KEGFRKDR | |
| SCHEMBL8256959 | 0.73 | EIF2AK2 (0.62) | BRAFTNNI3KEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015178955-A1 | SUBSTITUTED ETHYNYL HETEROBICYCLIC COMPOUNDS AS TYROSINE KINASE INHIBITORS | Eternity Bioscience Inc. (US) | 2015-11-26 | — | — | WO | disclosed |