Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.55 |
| ▸ | RET | P07949 | 3/20 | 0.55 |
| ▸ | KIF5B | P33176 | 3/20 | 0.55 |
| ▸ | BRAF | P15056 | 4/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 8/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559336 | 0.84 | KDR (0.63) | KDRRETKIF5BBRAFTNNI3K | |
| SCHEMBL5559096 | 0.79 | BRAF (0.53) | KDRRETKIF5BBRAFTNNI3K | |
| SCHEMBL17282952 | 0.76 | BRAF (0.65) | KDRRETBRAFTNNI3KEGFR | |
| SCHEMBL4770875 | 0.76 | CSF1R (0.52) | KDRRETKIF5BBRAFTNNI3K | |
| SCHEMBL4768902 | 0.73 | CSF1R (0.51) | BRAFTNNI3KEGFR | |
| SCHEMBL16962073 | 0.72 | MKNK1 (0.73) | RETBRAFTNNI3KEGFRFLT1 | |
| SCHEMBL15618296 | 0.72 | MKNK1 (0.58) | KDRBRAFTNNI3KEGFRMAPT | |
| SCHEMBL15618410 | 0.72 | BRAF (0.48) | KDRBRAFTNNI3KEGFR | |
| SCHEMBL4768916 | 0.71 | KDR (0.51) | KDRRETBRAFTNNI3KEGFR | |
| SCHEMBL5651286 | 0.71 | KDR (1.00) | KDRRETKIF5BBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
| WO-2004093812-A2 | COMPOUNDS THAT INDUCE NEURONAL DIFFERENTIATION IN EMBRYONIC STEM CELLS | IRM LLC (BM) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | FER, ERBB3, FLT3 | KDR 107/4885RET 15/4885KIF5B 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.