Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.37 |
| ▸ | PIM1 | P11309 | 7/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16588194 | 0.92 | PIM2 (0.41) | MAP4K4MAPTEIF2AK4PIM2PIM1 | |
| SCHEMBL16588195 | 0.89 | GPR119 (0.38) | MAP4K4EIF2AK4PIM2PIM1PIM3 | |
| SCHEMBL15883540 | 0.89 | PIM2 (0.45) | MAP4K4MAPTKDM4EALDH1A1GLA | |
| SCHEMBL15588848 | 0.88 | PIM1 (0.40) | MAP4K4MAPTEIF2AK4PIM2PIM1 | |
| SCHEMBL13456795 | 0.87 | EIF2AK4 (0.40) | MAP4K4MAPTKDM4EALDH1A1GLA | |
| SCHEMBL13707585 | 0.87 | EIF2AK4 (0.40) | MAP4K4MAPTKDM4EALDH1A1GLA | |
| SCHEMBL19371200 | 0.86 | EIF2AK4 (0.36) | MAP4K4MAPTKDM4EALDH1A1GLA | |
| SCHEMBL15818198 | 0.86 | PIM2 (0.36) | MAP4K4MAPTKDM4EALDH1A1GLA | |
| SCHEMBL15589027 | 0.86 | PIM2 (0.42) | MAP4K4MAPTKDM4EALDH1A1GLA | |
| SCHEMBL18430030 | 0.86 | MAP4K4 (0.35) | MAP4K4MAPTKDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336960-A1 | ARYL-SUBSTITUTED FUSED BICYCLIC PYRIDAZINE COMPOUNDS | NOVARTIS AG (CH) | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336960-A1 | ARYL-SUBSTITUTED FUSED BICYCLIC PYRIDAZINE COMPOUNDS | PIM1, PIM2, PIM3 | MAP4K4 13/4885MAPT 82/4885KDM4E 2213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.