Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 9/20 | 0.45 |
| ▸ | DRD4 | P21917 | 9/20 | 0.45 |
| ▸ | DRD3 | P35462 | 9/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729079 | 0.92 | GAA (0.62) | GAATAAR1DRD2DRD4DRD3 | |
| SCHEMBL6082947 | 0.88 | DRD4 (0.57) | GAADRD2DRD4DRD3LTA4H | |
| SCHEMBL1728525 | 0.87 | DRD2 (0.59) | GAATAAR1DRD2DRD4DRD3 | |
| SCHEMBL1727387 | 0.82 | MEN1 (0.53) | GAATAAR1DRD2DRD4DRD3 | |
| SCHEMBL1728589 | 0.82 | DRD2 (0.53) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL6081354 | 0.81 | DRD2 (0.56) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL1728672 | 0.81 | DRD2 (0.47) | GAATAAR1DRD2DRD4DRD3 | |
| SCHEMBL6080989 | 0.79 | DRD2 (0.50) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL1728536 | 0.78 | HTR1B (0.58) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL1728578 | 0.78 | KDM4E (0.48) | DRD2DRD4DRD3ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |