Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12746097 | 0.95 | SMN1; SMN2 (0.55) | SMN1; SMN2DRD2DRD4DRD3KDM4E | |
| SCHEMBL7144506 | 0.91 | SMN1; SMN2 (0.54) | SMN1; SMN2DRD2DRD4DRD3KDM4E | |
| SCHEMBL29690388 | 0.91 | SMN1; SMN2 (0.54) | SMN1; SMN2DRD2DRD4DRD3KDM4E | |
| SCHEMBL19806820 | 0.89 | MAPK1 (0.50) | SMN1; SMN2KDM4EL3MBTL1KMT2ANPSR1 | |
| SCHEMBL29083526 | 0.85 | DRD2 (0.61) | SMN1; SMN2DRD2DRD4DRD3KDM4E | |
| SCHEMBL11674802 | 0.85 | DRD2 (0.66) | SMN1; SMN2DRD2DRD4DRD3KDM4E | |
| SCHEMBL17138218 | 0.83 | RARB (0.49) | SMN1; SMN2KDM4EL3MBTL1HSD17B10KMT2A | |
| SCHEMBL10798638 | 0.83 | DRD2 (0.64) | SMN1; SMN2DRD2DRD4DRD3KDM4E | |
| SCHEMBL29381067 | 0.82 | DRD2 (0.62) | SMN1; SMN2DRD2DRD4DRD3KDM4E | |
| SCHEMBL27465 | 0.82 | DRD2 (0.62) | SMN1; SMN2DRD2DRD4DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336925-A1 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY (US) | 2015-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336925-A1 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCLAF1 | SMN1; SMN2 2273/4885DRD2 3586/4885DRD4 3616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.