Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727554 | 0.82 | MCHR1 (0.49) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1729072 | 0.80 | MCHR1 (0.47) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1728609 | 0.79 | MCHR1 (0.47) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1728662 | 0.78 | MCHR1 (0.47) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6080985 | 0.76 | MCHR1 (0.54) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6081522 | 0.76 | ALDH1A1 (0.55) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6081903 | 0.76 | MCHR1 (0.54) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6081338 | 0.75 | MCHR1 (0.51) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1728477 | 0.75 | MCHR1 (0.56) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6081331 | 0.75 | MCHR1 (0.53) | MCHR1MAPK14CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |