Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.61 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.51 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28514589 | 0.95 | ESR1 (0.69) | ESR1VCAM1LMNAMAPK1ALDH1A1 | |
| SCHEMBL9489683 | 0.95 | ESR1 (0.69) | ESR1VCAM1LMNAMAPK1ALDH1A1 | |
| SCHEMBL18134964 | 0.95 | ESR1 (0.69) | ESR1VCAM1LMNAMAPK1ALDH1A1 | |
| SCHEMBL17287371 | 0.90 | ESR1 (0.58) | ESR1LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL260606 | 0.86 | KMT2A (0.64) | VCAM1LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL3647689 | 0.85 | ESR1 (0.66) | ESR1LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL2648155 | 0.85 | VCAM1 (0.57) | VCAM1LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL2660151 | 0.85 | VCAM1 (0.60) | VCAM1LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL28978011 | 0.84 | KMT2A (0.51) | ESR1LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL17542258 | 0.84 | ESR1 (0.61) | ESR1LMNAMAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233165-B2 | Cyclopropylamine compounds as histone demethylase inhibitors | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2019-03-19 | — | — | US | disclosed |
| EP-3148974-B1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | ST EUROPEO DI ONCOLOGIA S R L (IT) | 2018-09-26 | — | — | EP | disclosed |
| US-20170190680-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-07-06 | — | — | US | disclosed |
| EP-3148974-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181380-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2015-12-03 | — | — | WO | disclosed |
| EP-2949648-A1 | Cyclopropylamine derivatives as histone demethylase inhibitors | IEO - Istituto Europeo di Oncologia Srl (IT) | 2015-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233165-B2 | Cyclopropylamine compounds as histone demethylase inhibitors | KDM1B, PHF2, KDM6B | ESR1 2969/4885VCAM1 2768/4885LMNA 3754/4885 |
| US-20170190680-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | KDM1B, PHF2, KDM6B | ESR1 2969/4885VCAM1 2768/4885LMNA 3754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.