Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 20/20 | 0.64 |
| ▸ | MMP2 | P08253 | 18/20 | 0.64 |
| ▸ | MMP9 | P14780 | 13/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.56 |
| ▸ | MMP3 | P08254 | 7/20 | 0.55 |
| ▸ | MMP1 | P03956 | 3/20 | 0.55 |
| ▸ | MMP12 | P39900 | 1/20 | 0.55 |
| ▸ | MMP14 | P50281 | 1/20 | 0.55 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17288031 | 0.92 | ADAM10 (0.62) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL17288023 | 0.89 | ADAM10 (0.75) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL1365282 | 0.88 | ADAM10 (0.78) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL1365960 | 0.88 | ADAM10 (0.78) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL17288045 | 0.86 | ADAM10 (0.68) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL17288038 | 0.81 | ADAM10 (0.75) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL1365285 | 0.81 | ADAM10 (0.83) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL1364006 | 0.81 | ADAM10 (0.83) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL1365030 | 0.80 | ADAM10 (0.76) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL1366404 | 0.80 | ADAM10 (0.76) | ADAM10MMP2MMP9ERBB2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622569-B1 | AZA SPIRO ALKANE DERIVATIVES AS INHIBITORS OF METALLPROTEASES | INCYTE CORP (US) | 2015-12-02 | — | — | EP | claimed |