Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.49 |
| ▸ | STK3 | Q13188 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729081 | 0.94 | ROCK2 (0.58) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL876735 | 0.93 | ROCK2 (0.59) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL3808498 | 0.89 | ROCK2 (0.57) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL3794722 | 0.83 | ROCK2 (0.71) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL1727391 | 0.82 | ROCK2 (0.74) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL3808492 | 0.82 | ROCK2 (0.59) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL877209 | 0.81 | ROCK2 (0.60) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL877574 | 0.81 | ROCK2 (0.67) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL877789 | 0.80 | ROCK2 (0.61) | ROCK2ROCK1CSNK2A1STK3AURKB | |
| SCHEMBL878381 | 0.79 | ROCK2 (0.67) | ROCK2ROCK1CSNK2A1STK3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406236-A1 | RHO KINASE INHIBITORS | Surface Logix, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104851-A1 | RHO KINASE INHIBITORS | SURFACE LOGIX, INC. (US) | 2010-09-16 | — | — | WO | disclosed |