Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.40 |
| ▸ | HTR3B | O95264 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | SORD | Q00796 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727715 | 0.89 | KDM4E (0.44) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL1728164 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL241458 | 0.77 | DRD3 (0.41) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL1727897 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL241135 | 0.75 | SORD (0.53) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL1727690 | 0.74 | POLB (0.44) | KDM4EALDH1A1CYP3A4CYP1A2SMN1; SMN2 | |
| SCHEMBL5779091 | 0.73 | KDM4E (0.50) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL1729344 | 0.73 | KDM4E (0.44) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 | |
| SCHEMBL1727647 | 0.73 | MAP4K4 (0.40) | PDE10APDE2A | |
| SCHEMBL239857 | 0.72 | HRH3 (0.46) | KDM4EALDH1A1CYP3A4HSD17B10HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |