Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 4/20 | 0.69 |
| ▸ | KDM4B | O94953 | 4/20 | 0.69 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.69 |
| ▸ | KDM5C | P41229 | 2/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.67 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | PHGDH | O43175 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663937 | 0.84 | PHGDH (0.71) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL29978391 | 0.84 | PHGDH (0.71) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL665571 | 0.82 | ADORA3 (0.78) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL663017 | 0.80 | ADORA3 (0.70) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL31361484 | 0.78 | ADORA3 (0.90) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL663246 | 0.78 | MEN1 (0.71) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL19763217 | 0.77 | ADORA3 (0.74) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL31361475 | 0.77 | ADORA3 (0.81) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL18997298 | 0.77 | KDM4A (0.72) | KDM4AKDM4BKDM5BKDM5CADORA3 | |
| SCHEMBL3401849 | 0.77 | SLC2A1 (0.74) | KDM4AKDM4BKDM5BADORA3GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |