Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 11/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295290 | 1.00 | S1PR1 (0.50) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295639 | 0.92 | S1PR1 (0.48) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295641 | 0.92 | S1PR1 (0.48) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295428 | 0.89 | FAAH (0.44) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295426 | 0.89 | FAAH (0.44) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295394 | 0.87 | FAAH (0.63) | S1PR1S1PR3ALDH1A1MAPTFAAH | |
| SCHEMBL17295390 | 0.87 | FAAH (0.63) | S1PR1S1PR3ALDH1A1MAPTFAAH | |
| SCHEMBL17302229 | 0.86 | FAAH (0.63) | S1PR1S1PR3ALDH1A1MAPTFAAH | |
| SCHEMBL17295529 | 0.86 | S1PR1 (0.45) | S1PR1S1PR3ALDH1A1MAPTHPGD | |
| SCHEMBL17295527 | 0.86 | S1PR1 (0.45) | S1PR1S1PR3ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |