Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 3/20 | 0.42 |
| ▸ | SI | P14410 | 3/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29726499 | 1.00 | S1PR1 (0.44) | S1PR1S1PR3MAPTALDH1A1HPGD | |
| SCHEMBL17295365 | 1.00 | S1PR1 (0.44) | S1PR1S1PR3MAPTALDH1A1HPGD | |
| SCHEMBL17295343 | 0.96 | S1PR1 (0.47) | S1PR1S1PR3MAPTALDH1A1HPGD | |
| SCHEMBL17295344 | 0.96 | S1PR1 (0.47) | S1PR1S1PR3MAPTALDH1A1HPGD | |
| SCHEMBL17295542 | 0.85 | S1PR1 (0.54) | S1PR1S1PR3MAPTALDH1A1HPGD | |
| SCHEMBL17295541 | 0.85 | S1PR1 (0.54) | S1PR1S1PR3MAPTALDH1A1HPGD | |
| SCHEMBL17295410 | 0.84 | S1PR1 (0.52) | S1PR1S1PR3ALDH1A1FAAHMEN1 | |
| SCHEMBL17295412 | 0.84 | S1PR1 (0.52) | S1PR1S1PR3ALDH1A1FAAHMEN1 | |
| SCHEMBL17295428 | 0.84 | FAAH (0.44) | S1PR1S1PR3MAPTALDH1A1HPGD | |
| SCHEMBL17295426 | 0.84 | FAAH (0.44) | S1PR1S1PR3MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |