Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 10/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17389 | 0.93 | HSD11B1 (0.35) | RORCNR1I2HSD11B1KCNH2CYP3A4 | |
| SCHEMBL17668 | 0.89 | HSD11B1 (0.34) | RORCNR1I2HSD11B1KCNH2CYP3A4 | |
| SCHEMBL16466 | 0.89 | HSD11B1 (0.39) | RORCHSD11B1KCNH2CYP3A4 | |
| SCHEMBL17452 | 0.87 | HSD11B1 (0.32) | HSD11B1KCNH2CYP3A4 | |
| SCHEMBL16964 | 0.86 | HSD11B1 (0.31) | HSD11B1KCNH2 | |
| SCHEMBL18345 | 0.85 | HSD11B1 (0.31) | HSD11B1KCNH2 | |
| SCHEMBL17547 | 0.84 | HSD11B1 (0.31) | HSD11B1KCNH2 | |
| SCHEMBL16074 | 0.83 | HSD11B1 (0.34) | RORCNR1I2HSD11B1KCNH2CYP3A4 | |
| SCHEMBL16912 | 0.83 | HSD11B1 (0.34) | RORCNR1I2HSD11B1KCNH2CYP3A4 | |
| SCHEMBL18340 | 0.83 | HSD11B1 (0.32) | RORCNR1I2HSD11B1KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |