Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17296639 | 0.90 | BRAF (0.45) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296645 | 0.90 | BRAF (0.72) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296642 | 0.87 | BRAF (0.46) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296638 | 0.85 | BRAF (0.48) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17685240 | 0.85 | BRAF (0.44) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL12482617 | 0.83 | BRAF (0.52) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296640 | 0.83 | BRAF (0.43) | BRAFNR1I2RAF1 | |
| SCHEMBL12482620 | 0.83 | BRAF (0.50) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296635 | 0.82 | BRAF (0.43) | BRAFNR1I2EGFR | |
| SCHEMBL17296637 | 0.82 | BRAF (0.43) | BRAFNR1I2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678336-B1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-04-20 | — | — | EP | disclosed |
| EP-2678336-B1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-04-20 | — | — | EP | disclosed |
| US-9199979-B2 | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-01 | — | — | US | disclosed |
| US-9199979-B2 | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-01 | — | — | US | disclosed |