Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12482308 | 0.91 | BRAF (0.47) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL12482633 | 0.90 | BRAF (0.41) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL12482614 | 0.89 | BRAF (0.39) | BRAFNR1I2 | |
| SCHEMBL17296642 | 0.87 | BRAF (0.46) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296641 | 0.85 | BRAF (0.57) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296639 | 0.83 | BRAF (0.45) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296648 | 0.79 | BRAF (0.45) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL12482620 | 0.79 | BRAF (0.50) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL12482617 | 0.79 | BRAF (0.52) | BRAFNR1I2EGFRRAF1ERBB2 | |
| SCHEMBL17296647 | 0.79 | BRAF (0.57) | BRAFNR1I2EGFRRAF1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678336-B1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-04-20 | — | — | EP | disclosed |