Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.59 |
| ▸ | KLK7 | P49862 | 6/20 | 0.58 |
| ▸ | KLK14 | Q9P0G3 | 6/20 | 0.58 |
| ▸ | KLK5 | Q9Y337 | 6/20 | 0.58 |
| ▸ | CTSG | P08311 | 5/20 | 0.58 |
| ▸ | CTRC | Q99895 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17554019 | 0.85 | KLK7 (0.72) | ALDH1A1HPGDKMT2AF2KLK7 | |
| SCHEMBL22952908 | 0.85 | KLK7 (0.67) | ALDH1A1HPGDKMT2AKLK7KLK14 | |
| SCHEMBL822512 | 0.85 | ALDH1A1 (0.50) | ALDH1A1HPGDKMT2AF2KLK7 | |
| SCHEMBL8499615 | 0.84 | KMT2A (0.70) | ALDH1A1HPGDKMT2AF2KLK7 | |
| SCHEMBL915062 | 0.80 | KMT2A (0.64) | ALDH1A1HPGDKMT2AKLK7KLK14 | |
| SCHEMBL914160 | 0.79 | KLK7 (0.60) | ALDH1A1HPGDKMT2AKLK7KLK14 | |
| SCHEMBL914308 | 0.78 | KMT2A (0.65) | ALDH1A1HPGDKMT2AF2KLK7 | |
| SCHEMBL914043 | 0.78 | HSD17B10 (0.63) | ALDH1A1HPGDKMT2AKLK7KLK14 | |
| SCHEMBL913997 | 0.77 | KMT2A (0.67) | ALDH1A1HPGDKMT2AF2KLK7 | |
| SCHEMBL914010 | 0.77 | KDM4E (0.58) | ALDH1A1HPGDKMT2AKLK7KLK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198891-B2 | Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase | NEW YORK UNIVERSITY (US) | 2015-12-01 | — | — | US | disclosed |