Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 7/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17300152 | 0.89 | GCK (0.53) | GCKMAPTGRM1EGFRLCK | |
| SCHEMBL17300137 | 0.88 | GCK (0.47) | GCKMAPTGRM1EGFRLCK | |
| SCHEMBL14667251 | 0.88 | GCK (0.48) | GCKMAPTGRM1EGFRLCK | |
| SCHEMBL17300146 | 0.87 | GCK (0.47) | GCKMAPTGRM1EGFRLCK | |
| SCHEMBL12289434 | 0.86 | GCK (0.46) | GCKMAPTGRM1EGFRERBB2 | |
| SCHEMBL12292146 | 0.86 | GCK (0.45) | GCKMAPTGRM1EGFRERBB2 | |
| SCHEMBL2642299 | 0.77 | GCK (0.44) | GCKMAPTGRM1EGFRLCK | |
| SCHEMBL2642216 | 0.77 | MAPT (0.44) | GCKMAPTGRM1EGFRLCK | |
| SCHEMBL2642274 | 0.76 | GCK (0.41) | GCKMAPTGRM1EGFRERBB2 | |
| SCHEMBL2643951 | 0.76 | GCK (0.41) | GCKMAPTGRM1EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558461-B1 | NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME | BRISTOL MYERS SQUIBB CO (US) | 2015-12-02 | — | — | EP | disclosed |