Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phenanthroline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.58 |
| ▸ | CCR1 | P32246 | 5/20 | 0.94 |
| ▸ | CCR8 | P51685 | 5/20 | 0.94 |
| ▸ | LMNA | P02545 | 4/20 | 0.94 |
| ▸ | CCR5 | P51681 | 3/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.94 |
| ▸ | MMP2 | P08253 | 2/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | MAPT | P10636 | 2/20 | 0.94 |
| ▸ | HTT | P42858 | 2/20 | 0.94 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.94 |
| ▸ | GMNN | O75496 | 1/20 | 0.94 |
| ▸ | TP53 | P04637 | 1/20 | 0.94 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.94 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.94 |
| ▸ | MMP9 | P14780 | 1/20 | 0.94 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.94 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenanthroline SCHEMBL29467763 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL7765519 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL7904213 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL29506434 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL30649310 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL31300436 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL8686807 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL5465049 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL999010 | 0.97 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL8685731 | 0.97 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110075927-B | Synthesis method of chloroethylene | 浙江工业大学 | 2021-12-21 | — | — | CN | claimed |
| EP-1788392-A1 | Biosensor and its use | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) | 2007-05-23 | — | — | EP | claimed |
| EP-1206288-B1 | TARGETED FIBERLESS RADIATIVE EFFECTORS | UNIV MICHIGAN (US) | 2007-01-10 | — | — | EP | claimed |
| US-11739022-B2 | Functionalised bimodal periodic mesoporous organosilicates (PMOS) and method for producing same using pseudomorphic transformation | Sentronic GmbH Gesellschaft für optische Meßsysteme (DE) | 2023-08-29 | — | — | US | disclosed |
| US-20220144692-A1 | FUNCTIONALISED BIMODAL PERIODIC MESOPOROUS ORGANOSILICATES (PMOS) AND METHOD FOR PRODUCING SAME USING PSEUDOMORPHIC TRANSFORMATION | Sentronic GmbH Gesellschaft für optische Meßsysteme (DE) | 2022-05-12 | — | — | US | disclosed |
| US-11261126-B2 | Functionalised bimodal periodic mesoporous organosilicates (PMOs) and method for producing same using pseudomorphic transformation | Sentronic GmbH Gesellschaft für optische Meßsysteme (DE) | 2022-03-01 | — | — | US | disclosed |
| CN-110075927-B | Synthesis method of chloroethylene | 浙江工业大学 | 2021-12-21 | — | — | CN | disclosed |
| US-20210311068-A1 | METHODS AND COMPOSITIONS RELATED TO MODIFIED GREEN FLUORESCENT PROTEIN (GFP) WITH AN EMBEDDED FOREIGN PEPTIDE | UNIVERSITY OF SOUTH FLORIDA | 2021-10-07 | — | — | US | disclosed |
| CN-107057454-B | Ink for manufacturing luminous layer, preparation method and application | 上海幂方电子科技有限公司 | 2021-04-13 | — | — | CN | disclosed |
| CN-109521073-B | Method for detecting content of bisphenol A by using electrochemical luminescence aptamer sensor | 中国农业科学院农业质量标准与检测技术研究所 | 2021-02-26 | — | — | CN | disclosed |
| US-20210032157-A1 | FUNCTIONALISED BIMODAL PERIODIC MESOPOROUS ORGANOSILICATES (PMOS) AND METHOD FOR PRODUCING SAME USING PSEUDOMORPHIC TRANSFORMATION | Sentronic GmbH Gesellschaft für optische Meßsysteme (DE) | 2021-02-04 | — | — | US | disclosed |
| US-20070111251-A1 | Chemical address tags | REGENTS OF THE UNIVERSITY OF MICHIGAN, THE | 2007-05-17 | — | — | US | disclosed |
| EP-1206288-B1 | TARGETED FIBERLESS RADIATIVE EFFECTORS | UNIV MICHIGAN (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005022362-A2 | CHEMICAL ADDRESS TAGS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2005-03-10 | — | — | WO | disclosed |
| US-20050042753-A1 | Artificial micelles comprising magnetic nanoparticle and therapeutic composition for use in tissue targeted therapy and side effect reduction | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2005-02-24 | — | — | US | disclosed |
| WO-2004026252-A2 | GLIOMA TREATMENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2004-04-01 | — | — | WO | disclosed |
| EP-1206288-A2 | TARGETED FIBERLESS RADIATIVE EFFECTORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2002-05-22 | — | — | EP | disclosed |
| EP-0870189-B1 | OPTICAL TEMPERATURE SENSORS AND OPTICAL-CHEMICAL SENSORS WITH OPTICAL TEMPERATURE COMPENSATION | MAX PLANCK GESELLSCHAFT (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001008660-A2 | TARGETED FIBERLESS RADIATIVE EFFECTORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2001-02-08 | — | — | WO | disclosed |
| WO-1994010553-A1 | FIBRE-OPTIC PROBE FOR THE MEASUREMENT OF FLUID PARAMETERS | OPTEX BIOMEDICAL, INC. (US) | 1994-05-11 | — | — | WO | disclosed |