Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 14/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1729157 | 0.92 | F2R (0.69) | F2RALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL14449142 | 0.92 | F2R (0.69) | F2RALDH1A1MEN1KMT2AL3MBTL1 | |
| Methylamine SCHEMBL1730461 | 0.90 | F2R (0.70) | F2RALDH1A1MEN1KMT2AL3MBTL1 | |
| Bromide SCHEMBL1731007 | 0.88 | F2R (0.65) | F2RALDH1A1MEN1KMT2AL3MBTL1 | |
| Bromide SCHEMBL1731033 | 0.87 | F2R (0.68) | F2RALDH1A1MEN1KMT2AL3MBTL1 | |
| Bromide SCHEMBL5491806 | 0.86 | F2R (0.61) | F2RALDH1A1MEN1KMT2AL3MBTL1 | |
| Bromide SCHEMBL1730396 | 0.86 | F2R (0.60) | F2RKDM4EMAPTNPC1RAB9A | |
| SCHEMBL14449151 | 0.85 | F2R (0.59) | F2RKDM4EMAPTNPC1RAB9A | |
| Bromide SCHEMBL5490738 | 0.84 | F2R (0.59) | F2RALDH1A1MEN1KMT2AL3MBTL1 | |
| Bromide SCHEMBL1729568 | 0.84 | F2R (0.58) | F2RKDM4EMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |