Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 16/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1730893 | 0.99 | F2R (0.83) | F2RKDM4ESMN1; SMN2LMNAMAPT | |
| SCHEMBL12151694 | 0.93 | F2R (0.81) | F2RSMN1; SMN2MAPTKMT2ATSHR | |
| Bromide SCHEMBL1729586 | 0.93 | F2R (0.82) | F2RSMN1; SMN2MAPTKMT2ATSHR | |
| SCHEMBL1731119 | 0.93 | F2R (0.80) | F2RKMT2A | |
| SCHEMBL13950221 | 0.93 | F2R (0.85) | F2RKDM4EMAPT | |
| SCHEMBL14449152 | 0.93 | F2R (0.87) | F2RSMN1; SMN2MAPT | |
| SCHEMBL14449063 | 0.92 | F2R (0.79) | F2RKMT2A | |
| Bromide SCHEMBL1728939 | 0.92 | F2R (0.81) | F2RKMT2A | |
| SCHEMBL13628887 | 0.92 | F2R (0.88) | F2RALDH1A1 | |
| SCHEMBL13144389 | 0.92 | F2R (0.86) | F2RSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |
| US-7244730-B2 | 2-iminopyrrolidine derivatives | EISAI CO., LTD (JP) | 2007-07-17 | — | — | US | disclosed |
| EP-1614680-A2 | Process for preparing 2-iminopyrrolidine derivatives | Eisai Co., Ltd. (JP) | 2006-01-11 | — | — | EP | disclosed |