SCHEMBL17309755

SCHEMBL17309755

N[C@@H](CCSC[C@H]1O[C@@H](n2cnc3c(NCCc4ccc(-c5ccccc5)cc4)nc(Cl)nc32)[C@H](O)[C@@H]1O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ DNMT3B Q9UBC3 12/20 1.00
▸ DNMT1 P26358 12/20 1.00
▸ DOT1L Q8TEK3 5/20 0.63
▸ NT5E P21589 1/20 0.58
▸ PRMT1 Q99873 1/20 0.57
▸ ADORA3 P0DMS8 1/20 0.57
▸ ADORA2A P29274 1/20 0.57
▸ ADORA1 P30542 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5052474 1.00 DNMT3B (1.00) DNMT3BDNMT1DOT1LNT5EPRMT1
SCHEMBL30225680 1.00 DNMT3B (1.00) DNMT3BDNMT1DOT1LNT5EPRMT1
SCHEMBL30225642 0.89 DNMT3B (1.00) DNMT3BDNMT1DOT1LPRMT1
SCHEMBL17309766 0.89 DNMT3B (1.00) DNMT3BDNMT1DOT1LPRMT1
SCHEMBL5062461 0.89 DNMT3B (0.79) DNMT3BDNMT1DOT1LNT5EPRMT1
SCHEMBL5055207 0.85 DNMT3B (1.00) DNMT3BDNMT1DOT1LPRMT1
SCHEMBL30225688 0.85 DNMT3B (1.00) DNMT3BDNMT1DOT1LPRMT1
SCHEMBL14174643 0.85 DNMT3B (1.00) DNMT3BDNMT1DOT1LPRMT1
SCHEMBL17309760 0.85 DNMT3B (1.00) DNMT3BDNMT1DOT1LPRMT1
SCHEMBL5062568 0.84 ADORA1 (0.80) DNMT3BDNMT1NT5EADORA3ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2952182-B1 Compounds and methods for increasing the immune response to papillomavirus UNIV HEIDELBERG (DE) 2022-11-23 — — EP claimed
WO-2015185611-A1 COMPOUNDS AND METHODS FOR INCREASING THE IMMUNE RESPONSE TO PAPILLOMAVIRUS UNIVERSITÄTSKLINIKUM HEIDELBERG (DE) 2015-12-10 — — WO claimed
EP-2952182-A1 Compounds and methods for increasing the immune response to papillomavirus Universitätsklinikum Heidelberg (DE) 2015-12-09 — — EP claimed
US-20250161351-A1 CANCER TREATMENT BY ARSENIC TRIOXIDE COMBINATION THERAPY Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2025-05-22 — — US disclosed
EP-4536250-A1 CANCER TREATMENT BY ARSENIC TRIOXIDE COMBINATION THERAPY Deutsches Krebsforschungszentrum (DE) 2025-04-16 — — EP disclosed
WO-2023237710-A1 CANCER TREATMENT BY ARSENIC TRIOXIDE COMBINATION THERAPY Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2023-12-14 — — WO disclosed
EP-2952182-B1 Compounds and methods for increasing the immune response to papillomavirus UNIV HEIDELBERG (DE) 2022-11-23 — — EP disclosed
WO-2015185611-A1 COMPOUNDS AND METHODS FOR INCREASING THE IMMUNE RESPONSE TO PAPILLOMAVIRUS UNIVERSITÄTSKLINIKUM HEIDELBERG (DE) 2015-12-10 — — WO disclosed
EP-2952182-A1 Compounds and methods for increasing the immune response to papillomavirus Universitätsklinikum Heidelberg (DE) 2015-12-09 — — EP disclosed
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