⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17312421 | 1.00 | — | — | |
| SCHEMBL17312618 | 0.83 | — | — | |
| SCHEMBL17312617 | 0.83 | — | — | |
| SCHEMBL15956959 | 0.78 | RIPK1 (0.40) | — | |
| SCHEMBL17312436 | 0.76 | NR3C2 (0.40) | — | |
| SCHEMBL17312434 | 0.76 | NR3C2 (0.40) | — | |
| SCHEMBL15964827 | 0.74 | GAA (0.48) | — | |
| SCHEMBL15964570 | 0.74 | BLM (0.31) | — | |
| SCHEMBL17312607 | 0.72 | RIPK1 (0.44) | — | |
| SCHEMBL17312606 | 0.72 | RIPK1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| US-9556152-B2 | Heterocyclic amides as kinase inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-01-31 | — | — | US | disclosed |
| US-20150353533-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-12-10 | — | — | US | disclosed |