Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17313511 | 0.90 | PDE4B (0.74) | PDE4BPDE4D | |
| SCHEMBL17313494 | 0.87 | PDE4B (0.73) | PDE4BPDE4D | |
| SCHEMBL17313524 | 0.87 | PDE4B (0.73) | PDE4BPDE4D | |
| SCHEMBL17313495 | 0.87 | PDE4B (1.00) | PDE4BPDE4D | |
| SCHEMBL17313512 | 0.87 | PDE4B (0.82) | PDE4BPDE4D | |
| SCHEMBL17313509 | 0.87 | PDE4B (0.82) | PDE4BPDE4D | |
| SCHEMBL18924224 | 0.85 | PDE4B (0.98) | PDE4BPDE4D | |
| SCHEMBL17313521 | 0.85 | PDE4B (0.76) | PDE4BPDE4D | |
| SCHEMBL17313523 | 0.85 | PDE4B (0.76) | PDE4BPDE4D | |
| SCHEMBL17313519 | 0.82 | PDE4B (0.74) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505724-B2 | 4-amino substituted condensed pyrimidine compounds as PDE4 inhibitors | Grünenthal GmbH (DE) | 2016-11-29 | — | — | US | disclosed |
| US-20150353507-A1 | 4-AMINO SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS AS PDE4 INHIBITORS | Grünenthal GmbH (DE) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353507-A1 | 4-AMINO SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS AS PDE4 INHIBITORS | PDE4A, PDE4B, PDE12 | PDE4B 2/4885PDE4D 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.