Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668472 | 0.92 | TSHR (0.52) | SRD5A2TP53TSHRAKT1AKT2 | |
| Hydrochloric Acid SCHEMBL4089589 | 0.90 | SRD5A2 (0.50) | SRD5A2TP53TSHRAKT1AKT2 | |
| SCHEMBL19331441 | 0.81 | RXRA (0.39) | TP53TSHRAKT1AKT2 | |
| SCHEMBL29223910 | 0.80 | SRD5A2 (0.50) | SRD5A2TP53TSHRAKT1AKT2 | |
| SCHEMBL9471910 | 0.79 | RXRA (0.56) | SRD5A2TP53TSHR | |
| SCHEMBL20768462 | 0.78 | TSHR (0.46) | SRD5A2TP53TSHR | |
| SCHEMBL17315678 | 0.78 | — | — | |
| SCHEMBL18662857 | 0.78 | AKT1 (0.50) | TSHRAKT1AKT2 | |
| SCHEMBL9472582 | 0.78 | ESR1 (0.57) | SRD5A2TP53TSHR | |
| SCHEMBL11894644 | 0.78 | TSHR (0.50) | SRD5A2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148971-A1 | DEUBIQUITINASE INHIBITORS | Pharmakea, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015187427-A1 | DEUBIQUITINASE INHIBITORS | PHARMAKEA, INC. (US) | 2015-12-10 | — | — | WO | disclosed |