Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 13/20 | 0.63 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17317318 | 1.00 | STING1 (0.63) | STING1FFAR1HTTMDM2 | |
| SCHEMBL2614589 | 1.00 | STING1 (0.63) | STING1FFAR1HTTMDM2 | |
| SCHEMBL14813748 | 0.92 | STING1 (0.61) | STING1FFAR1HTT | |
| SCHEMBL14813746 | 0.92 | STING1 (0.61) | STING1FFAR1HTT | |
| SCHEMBL14813745 | 0.92 | STING1 (0.61) | STING1FFAR1HTT | |
| SCHEMBL2098416 | 0.88 | MDM2 (0.67) | STING1MDM2 | |
| SCHEMBL17317149 | 0.88 | STING1 (0.63) | STING1FFAR1 | |
| SCHEMBL17317152 | 0.88 | STING1 (0.63) | STING1FFAR1 | |
| SCHEMBL29921322 | 0.88 | MDM2 (0.67) | STING1MDM2 | |
| SCHEMBL17317364 | 0.88 | MDM2 (0.67) | STING1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975853-B2 | Tetrahydroisoquinolinone derivatives and their use in the inhibition of the HSP70 protein | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2018-05-22 | — | — | US | disclosed |
| EP-3152193-B1 | TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN | HOLZGRABE ULRIKE (DE) | 2018-03-28 | — | — | EP | disclosed |
| US-20170152229-A1 | TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2017-06-01 | — | — | US | disclosed |
| EP-3152193-A1 | TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN | Julius-Maximilians-Universität Würzburg (DE) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015185114-A1 | TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2015-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152229-A1 | TETRAHYDROISOQUINOLINONE DERIVATIVES AND THEIR USE IN THE INHIBITION OF THE HSP70 PROTEIN | HSPH1, HSP90AB1, HSP90AB2P | STING1 1151/4885FFAR1 3758/4885HTT 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.