Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 13/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1730761 | 0.94 | F2R (0.41) | F2RPTGS2PTGS1ALOX5 | |
| Bromide SCHEMBL5488877 | 0.93 | F2R (0.39) | F2RPTGS2PTGS1ALOX5 | |
| Bromide SCHEMBL1730915 | 0.92 | F2R (0.40) | F2RPTGS2PTGS1ALOX5 | |
| Bromide SCHEMBL5485459 | 0.92 | F2R (0.38) | F2RPTGS2PTGS1ALOX5 | |
| Hydrochloric Acid SCHEMBL5488919 | 0.92 | F2R (0.38) | F2RPTGS2PTGS1ALOX5 | |
| Bromide SCHEMBL1729538 | 0.88 | F2R (0.39) | F2RPTGS2PTGS1ALOX5 | |
| Bromide SCHEMBL1730039 | 0.86 | F2R (0.37) | F2R | |
| Bromide SCHEMBL1732301 | 0.85 | PTGS2 (0.45) | F2RPTGS2PTGS1ALOX5 | |
| Bromide SCHEMBL1731907 | 0.85 | F2R (0.36) | F2RPTGS2PTGS1ALOX5 | |
| Bromide SCHEMBL1731616 | 0.83 | PTGS2 (0.47) | F2RPTGS2PTGS1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |