Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 5/20 | 0.37 |
| ▸ | GRM5 | P41594 | 6/20 | 0.35 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.35 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17319368 | 1.00 | EZH2 (0.38) | EZH2P2RX3P2RX2GRM5RAMP1 | |
| SCHEMBL17319370 | 1.00 | EZH2 (0.38) | EZH2P2RX3P2RX2GRM5RAMP1 | |
| SCHEMBL17319371 | 1.00 | EZH2 (0.38) | EZH2P2RX3P2RX2GRM5RAMP1 | |
| SCHEMBL14967357 | 1.00 | EZH2 (0.38) | EZH2P2RX3P2RX2GRM5RAMP1 | |
| SCHEMBL14969511 | 0.95 | EZH2 (0.40) | EZH2P2RX3P2RX2RAMP1CALCRL | |
| SCHEMBL14966673 | 0.87 | EED (0.44) | EZH2RAMP1CALCRLPDE4DKLKB1 | |
| SCHEMBL14967276 | 0.84 | P2RX3 (0.37) | EZH2P2RX3P2RX2GRM5PDE4D | |
| SCHEMBL14972094 | 0.82 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL14972238 | 0.82 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL14972130 | 0.82 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206128-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | disclosed |