Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 8/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.34 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10171484 | 0.86 | IRAK4 (0.47) | SYKIRAK4MAP3K7 | |
| SCHEMBL10172039 | 0.86 | IRAK4 (0.47) | SYKIRAK4MAP3K7 | |
| SCHEMBL12112150 | 0.77 | IRAK4 (0.37) | SYKIRAK4MAP3K7 | |
| SCHEMBL10171297 | 0.73 | ADORA3 (0.53) | — | |
| SCHEMBL10172030 | 0.73 | IRAK4 (0.47) | SYKIRAK4MAP3K7 | |
| SCHEMBL10171496 | 0.72 | IRAK4 (0.60) | SYKIRAK4MAP3K7 | |
| SCHEMBL10171485 | 0.71 | KDR (0.51) | SYKIRAK4MAP3K7CDK1CDK2 | |
| SCHEMBL10171260 | 0.71 | IRAK4 (0.51) | IRAK4MAP3K7 | |
| SCHEMBL12112326 | 0.71 | KDR (0.46) | SYKIRAK4MAP3K7 | |
| SCHEMBL14513339 | 0.71 | KDR (0.46) | SYKIRAK4MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960372-B1 | KINASE INHIBITORS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-12-09 | — | — | EP | disclosed |